SEMAX®
Pharmacology

COMPOSITION :

According to its structure, SEMAX® represents a synthetic analogue of the short fragment of Corticotropin, with no hormonal activities: ACTH (4-7) Pro-Gly-Pro.(Met-Glu-His-Phe-Pro-Gly-Pro)
The preparation is in the form of white crystalline hygroscopic powder, easily soluble in water. For clinical tests, SEMAX® was used in the form of nose drops (0.1% colorless transparent water solution with nipagin as conserving agent, in hermetically sealed bottles of 3.0ml, with pipette covers ,
pH = 4.0 - 5.5)

Pharmacological characteristics:

After intranasal application, 60-70% of SEMAX® is very quickly absorbed from the nasopharyngeal mucous membrane into the system circulation, thus as early as 1-5 minutes following its instillation the drug is accumulated in liver, adrenal glands, brain, heart, kidneys and skeletal muscles, which points to good distribution in the tissues.

Peak concentrations are achieved after 60 min.

Biotransformation develops through the action of aminopeptidases and angiotensin-converting enzyme to individual amino acids. Its half-life (t 1/2) is 4 min;

The therapeutic effect, after the application of a single dose, is maintained up to 20 hours. It is very rapidly excreted in urine via kidneys . Its half-life is : 0.4-5 minutes.