SEMAX®
Clinical and Technical Aspects
(continued)
BIOLOGICAL
EFFECTS OF SEMAX®
In the brain SEMAX® induces conformation
changes in receptors of neurons comprising the Limbic Reticular
complex leading to the increased generation of cAMP, c-GMP
as well as of eicosanoids and certain oligopeptides: somatostatin,
thyroliberin factor, cholecystokinin, dopamine, acetylcholine,
serotonine, adenosine and histamine.
Semax® regulates the activating and
inhibitory biosubstrate relation, NMDA receptors (glutamate,
aspartate, glycine, taurine) in the central and peripheral
nervous system, enhances the restitution of disturbed energy
metabolism of neurons and their adjacent environment, returns
the disarranged relation of neuron-astroglia function to
normal, augments the activation of apoptosis inhibition,
stimulates the modulation of synthesis of neurotrophins,
proteins and other biosubstrates for the impaired neuron’s
protection.
Semax®
increases mRNA for NGF by 500% and for BDNF by 800%
(Shadrina M.I, et al)
Semax®
inhibits the excessive generation of Nitic Oxide caused
by cerebral ischemia.
(Bashkatova V.G; Armstrong D., et
al)
Semax®
increases the level of anti-inflammatory cytokines like
IL-10, TGF-1ß and lowers the level of pro-inflammatory
cytokines like IL-8 and C-Reactive Protein
(Myasoedov N.F., Skvortsova V.I.,
et al )
Semax®
intensifies the expression of early genes that regulate
and activate the adaptation process of the impaired neurons,
it augments the activation of apoptosis inhibition by increasing
levels of Bcl-2.
(E.Gusev and Skvortsova V.I)
Maria
I. Shadrina, Oleg V. Dolotov, Igor A. Grivennikov, Petr
A. Slominsky *, Ludmila A. Andreeva, Ludmila S. Inozemtseva,
Svetlana A. Limborska, Nikolay F. Myasoedov /Neuroscience
Letters 308 (2001) 115-118
Myasoedov
N.F., Skvortsova V.I. et al,
“Mechanisms of Neuro-protective Effects of Semax®
in the Acute Period of Ischemic Insult” Zh.Nevrol.Psikhiatr.
Im., S.S. Korsakova, 99; 1999; 15-19
Valentina
G. Bashkatova, Vladimir B. Koshelev, Olga E. Fadyukova,
Alexandr A. Alexeev, Anatolii F. Vanin, Kirill S. Rayevsky,
Igor P. Ashmarin, David M. Armstrong *
/
Brain Research 894 (2001) 145–149
* Corresponding author, Thomas Jefferson University , Wynnewood
, PA 19096,USA
E.Gusev,
V.I. Skvortsova, Proc. 6th European Fed of Neuological.
Soc. Congress,Vienna,2002
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